The idea of a special interaction between mango and cannabis is widely shared. The references checked for this article do not demonstrate that eating a mango intensifies or prolongs the effects of cannabis in humans.
where does the entourage effect come from?
A publication by Ben-Shabat and colleagues used the concept as early as 1998. It concerns 2-arachidonoylglycerol, a cannabinoid produced by the body, and compounds that accompany it. Its experiments are not a clinical trial of the mango-cannabis combination.
In 2011, Russo's review Taming THC examined, among other things, possible interactions between the constituents of cannabis. It is a synthesis of hypotheses and research results, not the validation of a dietary tip aimed at changing the effects of cannabis.
a hypothesis is not enough
Moving from an interaction observed between substances in an experimental protocol to a predictable effect after eating a food requires specific evidence. The two publications cited do not allow this step to be taken for mango.
We therefore offer no method or advice for enhancing the effects of cannabis. The interest of the topic lies elsewhere: learning to tell an appealing explanation from a result that has actually been tested.
what this review does not settle
The lack of evidence in the sources examined is not proof that no interaction could ever be studied. It simply means the question must be presented as unestablished, and no medical benefits should be inferred from it.
